Agrochemical Genetic Toxicology Evaluations

Agrochemical Genetic Toxicology Evaluations

Agrochemical compound products may cause cancer through direct ingestion of residues on food and through indirect exposure. Globally, regulatory agencies require data for specific genetic toxicological endpoints for agrochemical products. At BOC Sciences, we understand the importance of characterizing the genetic toxicology of agrochemical product to meet the requirements of regulatory agencies, and our team is committed to providing comprehensive strategic support for genetic toxicology testing to help you handle different substances.

Introduction of Genetic Toxicology in Agrochemicals

Genotoxicity studies can be used to assess the mutagenic potential of various products prior to their widespread application in humans. Since DNA-reactive substances may initiate the carcinogenic processes, effective screening strategies are becoming increasingly useful for biological assessment of potential human risk. While genotoxicity testing is required for all classes of agrochemicals, the testing strategy should be adapted to the applicable regulatory requirements and the responses observed in vitro.

Figure 1. Evolutionary Toxicology as a Tool to Assess the Ecotoxicological Risk. (Sabella, S.; et al. 2014)

High Quality Agrochemical Genetic Toxicology Testing

In vitro assays

• OECD: Bacterial Reverse Mutation (Ames)
• OECD: In vitro Mammalian Chromosome Aberration Test (Human lymphocytes and CHL cell)
• OECD: In vitro Micronucleus Test (Human lymphocytes, L5178Y cells, TK6 cells)
• OECD: In vitro Mammalian Cell Gene Mutation Test MLA (L5178Y cells)
• OECD: In vitro Mammalian Cell Gene Mutation Test -HPRT (CHO cells and V79 cells)

In vivo assays

• OECD: Rodent Bone Marrow Micronucleus Test
• OECD: Rodent Comet Assay

Features of Our Services

• Strategic scientific and regulatory expertise in the optimization of your genotoxicology study program.
• All aspects of your agrochemical product’s genetic toxicology studies varying from concept through to data reporting and regulatory submission.
• BOC Sciences supports state-of-the-art facilities to ensure the delivery of robust and reliable results.

Figure 2. The genesis of cancer. (Salk, J. J.; et al. 2020)

BOC Sciences Advantages

• Highly specialized technical and analytical services for the worldwide registration and regulatory compliance of agrochemicals
• Robust analytical testing programs that span from research and product development through the production process to final product
• Relies on broad industrial experience, ensuring that all of our work meets the high standards expected by our clients
• Our regulatory experts, toxicology consultants, scientists and inspectors will ensure that you receive maximum levels of guidance, testing and inspection you need.

References

• Rusconi, M.; et al. Evolutionary Toxicology as a Tool to Assess the Ecotoxicological Risk in Freshwater Ecosystems. Water. 2018. 10(4): 490.
• Salk, J. J.; et al. Next-Generation Genotoxicology: Using Modern Sequencing Technologies to Assess Somatic Mutagenesis and Cancer Risk. Wiley-Blackwell Online Open. 2020. 61(1): 135-151.