Human Safety & Health
Developing innovative, breakthrough agrochemicals, and investigating the health and environmental impacts of novel chemicals is a key part of the development pathway. The use of these agrochemicals results in unintentional exposure to the environment, animals, and humans, posing potential health risks. Humans are often exposed to these agrochemicals during their application or production or consumption of foods containing pesticide residues. Therefore, in addition to testing the toxicity of agrochemical residues to the environment, animal and human health, there is a need to test their safety in relation to their intended use. Elimination of toxic substances and understand of the impact of chemicals on people and the environment is made easier with the latest predictive and mechanistic testing methods. In recent years, regulatory agencies for agrochemicals are introducing stricter standards around toxicology studies, and are implementing precise methods and techniques. However, determining whether a compound has toxic potential can be difficult, effects are also unpredictable and downstream consequences can be difficult to track. Understanding the readout of toxicity assays requires a thorough understanding of the complete mechanism of action and cross-species sensitivity. BOC Sciences has a strong foundation and reputation in the toxicological evaluation of agrochemical products. We have been at the forefront of toxicological testing; continually maintaining exceptional standards and innovating to improve research results and efficiency. Through thorough and early safety screening, we help our customers develop agrochemical products with better quality and a long marketable life.
Features of Our Services
- From in silico predictions using QSAR modeling to complex multigenerational in vivo DART studies, our team of experts has the expertise and insight you need.
- BOC Sciences has introduced a state-of-the-art infrastructure to ensure reliable and robust human toxicology data for your agrochemical products.
- From designing and managing a complete research program to running a single safety assessment, we can help address your specific needs according to your projects.
Figure 1. Environmental toxicology and its components. (Lee Yook, H.; et al. 2018)
Our Agrochemical Toxicology Studies
Supported by an in-house project management and quality team, we operate to the highest quality standards. Supported by an in-house project management and quality team, we operate to the highest quality standards. BOC Sciences has established GLP-certified laboratories that can provide GLP and non-GLP studies through predictive, exploratory and discovery toxicology. Our novel predictive and mechanical testing services include:
- Provide toxicology data for re-registration dossier in accordance with the latest regulatory requirements
- Create detailed comparative toxicological risk data across species
- Screen candidate compounds
- Help to develop products that are most beneficial to humans and the environment
We remain at the forefront of toxicology testing, constantly maintaining standards of excellence and innovation to improve research results and efficiency. BOC Sciences supports state-of-the-art infrastructure to ensure reliable, robust toxicology data for your agricultural compound products.
Agrochemical Non-genotoxic Carcinogenicity Evaluations
We collect extensive in-life, survival and histopathology data, and perform comprehensive statistical data analysis to evaluate tumor parameters and understand the human relevance of rodent toxicological findings.
Agrochemical Neurotoxicology Evaluations
BOC Sciences has established a novel safety testing platform based on the latest pluripotent stem cell and primary central nervous system cell-based assays, providing an accurate assessment of the potential neurotoxic effects of agrochemicals.
Agrochemical Endocrine Toxicology Evaluations
Our expert teams can offer a variety of testings by performing tailored mechanistic investigations to expertly assess the potential of chemicals to disrupt endocrine signaling.
Agrochemical In Silico Predictive Toxicology Evaluations
BOC Sciences has introduced a wide range of software available for toxicity prediction services, capable of providing reliable and accurate in silico predictive toxicology results for different toxicological endpoints.
Agrochemical In Vitro Toxicology Evaluations
Multiple in vitro testing methodologies are available to determine the potential impact of your agrochemical product on human safety. Our well-design in vitro experiment design and technology help to improve the reliability of in vitro toxicity studies.
Agrochemical General Toxicology Evaluations
Our extensive facilities, flexible capacity and cutting-edge laboratories allow us to conduct all general toxicology studies for your agrochemical and deliver high-quality results in a timely manner.
Figure 2. Computational toxicology model development workflow. (Kizhedath, A.; et al. 2016)
Agrochemical Genetic Toxicology Evaluations
In order to characterize the genetic toxicology of substances to meet the requirements of regulatory agencies, our team is committed to providing comprehensive strategic support for genetic toxicology testing to help you handle different substances.
Agrochemical Developmental and Reproductive Toxicology (DART) Evaluations
Our expert has scientific knowledge in histopathology, animal behavior and analysis that allow us to analyze all a diverse of DART endpoints. Moreover, we can conduct a comprehensive DART studies for your agrochemical products.
Agrochemical Inhalation Toxicology Evaluations
At BOC Sciences, we have accumulated rich experience and expertise to successfully test the effects of inhaled compounds, delivering safety assessment of inhalation toxicology required.
BOC Sciences Advantages
- Highly specialized technical and analytical services for the worldwide registration and regulatory compliance of agrochemicals
- Robust analytical testing programs that span from research and product development through the production process to final product
- Relies on broad industrial experience, ensuring that all of our work meets the high standards expected by our clients
- Our regulatory experts, toxicology consultants, scientists and inspectors will ensure that you receive maximum levels of guidance, testing and inspection you need.
References
- Lee Yook, H.; et al. Environmental Toxicity and Evaluation. Environmental Risk Analysis for Asian-Oriented. 2018.
- Kizhedath, A.; et al. Applicability of predictive toxicology methods for monoclonal antibody therapeutics: status Quo and scope. Archive für Toxikologie. 2016. 91(4): 1-18.