Agrochemical In Vitro Toxicology Evaluations

Agrochemical In Vitro Toxicology Evaluations

The application of agrochemicals such as crop protectants, veterinary disinfectants may lead to (un)intentional exposure of the environment, animals and humans. Therefore, scientists have developed a number of testing strategies based on in vitro models of animal organs and tissues to perform safety testings on agrochemicals. At BOC Sciences, multiple in vitro testing methodologies have been developed to determine the potential impact of your agrochemical product on human safety.

Advantages of Our In Vitro Toxicity Evaluations

• Our team of experts has over 20 years of experience in designing and conducting a comprehensive set of in vitro testings that meet globally recognized standards.
• BOC Sciences has become a leader in in vitro experiment design and technology that effectively improves the reliability of in vitro toxicity studies.
• We leverage insights gathered from the global regulatory environment to smooth the regulatory journey for different agrochemical products.

Figure 1. Chemical structures of synthetic pyrethroids (SPs) and their metabolites. (Ying, Z.; et al. 2010)

Agrochemical In Vitro Genotoxicity Studies

• Ames testing
• In vitro chromosomal aberration test in CHO cells
• In vitro mammalian cell gene mutation testing in CHO cells
• In vitro mammalian micronucleus testing in CHO cells

Extensive In Vitro Testing Capabilities

• Phototoxicity
• Cytotoxicity
• Skin corrosion: 3D models
• Skin irritation: 3D models
• Eye irritation: Isolated chicken eye testing (with optional histopathology)
• Skin sensitization: Direct peptide reactivity assay (DPRA) and human cell line activation testing (hCLAT)
• Endocrine disruption: Estrogen receptor agonist/antagonist, H295R steroidogenesis assay, and human recombinant estrogen receptor (hrER)

Figure 2. Metabolism of synthetic pyrethroids (SPs) in mammals. (Ying, Z.; et al. 2010)

Features of Our Services

• Our agrochemical in vitro toxicity testing team is comprised of experts from diverse backgrounds with extensive experience in planning and performing in vitro testing.
• Our team of experts includes toxicologists, biologists, analytical chemists and environmental scientists with extensive in vitro testing capabilities to characterize the safety of agrochemical products reliably.
• BOC Sciences has been at the forefront of in vitro testing of agricultural compounds, and has accumulated rich experience in in vitro toxicology studies.

BOC Sciences Advantages

• Highly specialized technical and analytical services for the worldwide registration and regulatory compliance of agrochemicals
• Robust analytical testing programs that span from research and product development through the production process to final product
• Relies on broad industrial experience, ensuring that all of our work meets the high standards expected by our clients
• Our regulatory experts, toxicology consultants, scientists and inspectors will ensure that you receive maximum levels of guidance, testing and inspection you need.

Reference

• Ying, Z.; et al. Immunotoxicity of pyrethroid metabolites in an in vitro model. Environmental Toxicology and Chemistry. 2010. 29 (11): 2505-2510.