Dermal Absorption Studies for Agrochemicals
There are multiple routes of exposure to agrochemicals via the skin through dermal absorption. Dermal absorption is an important component of non-dietary human safety risk assessment for agrochemicals. And it is a possible route of exposure for agricultural workers, so this route of exposure needs to be fully investigated. Typically, dermal absorption data for agrochemical actives are generated from undiluted formulation concentrates and its spray dilutions. BOC Sciences offers two types of dermal absorption studies-in vitro studies on human or animal skin and in vivo studies. We provide tailored dermal absorption testing approach according to the specific requirements of the crop protection product regulatory agency. Data from our dermal absorption studies are critical for your crop protection product safety information, which can help you to perform accurate exposure risk assessments.
Figure 1. General procedure for decision of dermal absorption value of plant protection products. (Harrie,B.; et al. 2017)
Reliable Dermal Absorption Studies
- OECD 427: Skin Absorption. In Vivo Method
- OECD 428: Skin Absorption. In vitro method
- oppts 870.7600: Dermal Penetration
Features of Our Services
- Our dermal absorption studies provide timely, high quality data for effective planning and technical support in the later stages of your crop protection product development.
- The method we use to assess the transfer of dried pesticide residues from a surface to the skin is reproducible for different active ingredients of diverse physicochemical properties.
- Our team is able to adapt experimental designs for volatile crop protection products to ensure mass balance.
- Our human in vitro studies are conducted on human skin obtained from approved sources. In addition, we support in vitro and in vivo studies in the rats to predict dermal absorption in humans.
- We have the ability to perform tests using radiolabeled test materials (employing flow-through cells). Or we can perform studies using non-radiolabeled test material, typically using static (Franz) cells.
Figure 2. Individual cell potential dermal absorption plotted against Mass Balance. (Kluxen, F. M.; et al. 2019)
BOC Sciences Advantages
- Highly specialized technical and analytical services for the worldwide registration and regulatory compliance of agrochemicals
- Robust analytical testing programs that span from research and product development through the production process to final product
- Relies on broad industrial experience, ensuring that all of our work meets the high standards expected by our clients
- Our regulatory experts, toxicology consultants, scientists and inspectors will ensure that you receive maximum levels of guidance, testing and inspection you need.
References
- Harrie,B.; et al. Guidance on Dermal Absorption. EFSA JOURNAL. 2017. 15(6).
- Kluxen, F. M.; et al. Dermal absorption study OECD TG 428 mass balance recommendations based on the EFSA database. Regulatory Toxicology and Pharmacology. 2019. 108: 104475.