Laboratory Animal Metabolism Studies for Agrochemicals
Metabolic studies in animal models (toxicokinetics) allow you to determine the absorption, distribution, metabolism and excretion (ADME) of your crop protection product. Therefore, data from animal metabolism studies are essential to assess the hazards and/or risks to humans from agrochemical products. BOC Sciences provides robust metabolism studies in a wide range of animal models to perform ADME of your crop protection product.
Features of Our Services
- BOC Sciences has a long history of conducting standard and custom metabolic studies for a variety of crop protection products, and we are able to design of research and development programs (for registration of novel veterinary and generic drugs to support desired label claims).
- With an established team of metabolic scientists who have worked in the crop protection products and assay industry for many years and have accumulated a wealth of scientific insight and practical experience, we are capable of designing and executing clinical protocols (efficacy and safety studies, discovery and development) to support required labeling requirements.
- Our flexible facilities are ready to support a variety of test species, and our expert teams can manage and coordinate existing development programs.
Metabolism in Laboratory Animal
Optimization of animal metabolism studies
- Select appropriate species of experimental animals
- Dose profile-how often and by what route
Exposure modelling
- Data gap analysis and testing strategy development
- Co-ordination of the regulatory dossier collection and submission
- Ensure on time product approvals
Inhalation ADME
We perform ADME studies to determine plasma and tissue kinetics, routes and rates of excretion and provide structural identification of metabolite. In addition to the standard OECD 417: Toxicokinetic studies, BOC Sciences has the expertise to design and conduct custom laboratory animal metabolism studies.
- Species: rats, mice, rabbits, dogs, primates and minipigs
- Dose administration: including oral, dermal, intravenous or inhalation administration for single or repeated doses
- Sample collection: including bile duct and duodenal cannulation in rats and dogs to study biliary excretion and portal vein cannulation to investigate the hepatic first-pass metabolism
Comprehensive toxicokinetic analysis
- Excretion/equilibrium
- Pharmacokinetics
- Tissue distribution, including quantitative whole-body audioradiography (QWBA)
- Biliary excretion
- Metabolite analysis and identification
BOC Sciences Advantages
- Highly specialized technical and analytical services for the worldwide registration and regulatory compliance of agrochemicals
- Robust analytical testing programs that span from research and product development through the production process to final product
- Relies on broad industrial experience, ensuring that all of our work meets the high standards expected by our clients
- Our regulatory experts, toxicology consultants, scientists and inspectors will ensure that you receive maximum levels of guidance, testing and inspection you need.