Animal Metabolism Studies for Agrochemicals
Crop protection products can penetrate the human food chain through residues left on crops or through animals that ingest residues in feed. The risk to human and animal health and the environment posed by herbicides, fungicides or insecticides has become an important issue for both consumers and regulatory agencies. Therefore, understanding animal metabolism is critical to help predict potential risks of crop protection products and to determine safe minimum residue levels. In recent years, scientists have used different toxicity studies in animals (mainly rats and mice) to examine the safety of crop protection products for human. In addition to metabolic data in livestock animals, studies involving bioinformatics and in vitro models have been used as alternatives to animal studies to obtain important data on compounds for agricultural use.
Figure 1. Metobolic profiling and identification of natural accessions. (Alseekh, S. 2022)
Livestock Metabolism Studies for Agrochemicals
Characterization of the nature and level of chemical residues accumulating in livestock helps determine the risk an agrochemical poses in the human food chain. We are capable of rapidly and efficiently hitting your livestock metabolism endpoints by building robust data sets.
Laboratory Animal Metabolism Studies for Agrochemicals
Metabolism studies (toxicokinetics) in animal models allow you to determine the absorption, distribution, metabolism and excretion (ADME) of crop protection products. BOC Sciences offers a variety of animal models with high scientific integrity, providing data for animal metabolism studies used to assess the hazards and/or risks posed by crop protection products to humans.
Features of Our Services
- Combining expertise and insight in analytical chemistry, environmental modeling, metabolite identification, animal health, and regulation, BOC Sciences' team of experts can design a research package that provides reliable data and sound scientific arguments to meet your specific animal metabolism needs.
- We provide clear evidence of where your crop protection product and its metabolites may end up.
- Data on the toxicity of crop protection products is also available.
Figure 2. Pathway analysis and metabolite-transcript analysis. (Alseekh, S. 2022)
BOC Sciences Advantages
- Highly specialized technical and analytical services for the worldwide registration and regulatory compliance of agrochemicals
- Robust analytical testing programs that span from research and product development through the production process to final product
- Relies on broad industrial experience, ensuring that all of our work meets the high standards expected by our clients
- Our regulatory experts, toxicology consultants, scientists and inspectors will ensure that you receive maximum levels of guidance, testing and inspection you need.
Reference
- Alseekh, S. The Genetics of Crop Metabolism. Max Planck Institute of Molecular Plant Physiology. 2022.