Livestock Metabolism Studies for Agrochemicals
Characterization of the nature and levels of chemical residues accumulating in livestock can help determine the risk posed by agrochemicals in the human food chain. Livestock metabolism studies and livestock feeding studies are late-stage, and represent a significant regulatory barrier to approval of agrochemicals because of their complexity of implementation. BOC Sciences is a reliable partner with a track record of livestock metabolism studies success. Our in vivo and in vitro livestock metabolism services include the ability to perform residue studies in major crops, processed products. We are able to perform life-cycle animal metabolism studies on multiple types of livestock. We design and plan every detail of the study to best meet the needs of agrochemical product development and/or regulatory compliance.
Metabolism in Livestock
Residue studies
Residue property studies are conducted using 14C-radiolabeled compounds to determine the distribution of radioactive residues in various tissue matrices and to identify the degradation pathways.
- The property of residue studies (OECD 501, OECD 502, OECD 503 and OECD 507) are conducted by experts and experienced staff in our laboratories.
- We support a series of services including Total radioactive residue, extractable residue, determination/characterization of bound residues (post extracted solids), matrix clean-up, and characterization / radio-profiles of the radioactive residue.
Metabolite profiling and characterization
- Combined with our laboratory's advanced chromatography and mass spectrometry instrumentation, our experienced metabolite identification chemists are able to elucidate the structure of novel metabolites.
- Once our experts in metabolism have determined the nature of the residue, our residue team experts will guide the client through any follow-up studies that may be required to determine the magnitude of the pesticide residue.
Standard livestock metabolism studies
- OECD 503: Metabolism in livestock
- OPPTS 860.340: Radiovalidation
- OECD 505: Residues in livestock
Radio-analytical Capability
Commercial farm scale trials, environmental risk assessments and both laboratory and field studies allows us to work with most livestock species. Such livestock include cattle, sheep, goats, pigs, rabbits and poultry. BOC Sciences supports radio-HPLC, radio-LC-MS/MS, radio-TLC, LSC, bio-imaging and combustion analysis to quantify residues and identify metabolites.
Features of Our Services
- Hit metabolic endpoints in livestock quickly and efficiently
- Utilize various chemical techniques to identify the key residues of concern
- Development of a diversity of radiolabeled test items (metabolic studies)
- Optimize extraction methods and validate analytical techniques to characterize residues
BOC Sciences Advantages
- Highly specialized technical and analytical services for the worldwide registration and regulatory compliance of agrochemicals
- Robust analytical testing programs that span from research and product development through the production process to final product
- Relies on broad industrial experience, ensuring that all of our work meets the high standards expected by our clients
- Our regulatory experts, toxicology consultants, scientists and inspectors will ensure that you receive maximum levels of guidance, testing and inspection you need.